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Biological & Pharmaceutical Bulletin
Vol. 31 (2008) , No. 3 449

trans-3,4Œ-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor ƒÀ2 (TGF-ƒÀ2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

Michiyo Sasajima1), et al

t-flavanone is a synthetic compound with hair regrowth enhancing activity that is effective against male pattern hair loss. t-Flavanone was designed as a derivative of astilbin, the active hair growth enhancing component of Hypericum perforatum extracts. This study was designed to elucidate the mechanism of hair regrowth enhancement by t-flavanone. snip... In order to investigate the effects of t-flavanone on TGF-ƒÀ2 activation by human keratinocytes, we evaluated the level of active TGF-ƒÀ2 converted from the inactive form in t-flavanone-treated human keratinocytes. snip... t-Flavanone is a hair regrowth enhancing component that has a novel mechanism of action which suppresses TGF-ƒÀ2 activation, and thereby is expected to have therapeutic effects on other types of hair loss in addition to male pattern hair loss.

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